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October 2025#

Welcome to the sixth edition of our monthly newsletter! We’re here to keep you in the loop with the latest SAMSON updates, new features, and what’s coming next.

In case you missed it last month, SAMSON 2025 R3 is out, and you can explore what's new and enhanced. Make sure to update to get the latest features (from the menu: Interface > Update SAMSON, or simply with the installer).

We also made SAMSON and all extensions free for non-commercial use, and we've been amazed by the incredible response from the community. Please continue to share the word, as SAMSON is even better in teams for collaborative work.

Extension Updates - October Highlights#

We’ve rolled out several powerful updates to SAMSON Extensions this month::

  • Interaction Designer: Improved interaction detection and enhanced stability.

    Interaction Designer

    In particular, the new dynamic layout feature makes it easy (and very fun 😀) to customize interaction diagrams! Check out this short video to see it in action:

  • SAMSON AI: Smarter NSL generation via the Document View filter, Find tool, and AI Assistant (through the AI commands /nsl and /select).

  • GROMACS Wizard: Now makes it possible to perform batch calculations for different systems at the same time (for different conformations of the same system, this was already possible for umbrella sampling).
  • OpenMM Wizard: Now supports OpenMM v8.4.0 for improved performance and features.
  • PDBFixer: Updated to PDBFixer v1.12 for better structure correction and compatibility.
  • Glycans visualization: Better recognition and display of diverse monosaccharide classes.

Minor improvements#

There were several improvements in Molecular Motif Grafter, Brenner interaction model and various importers (e.g., to import coarse-grained systems).

Also, the transparency of silhouettes is now independent of the transparency of the contoured objects:

Silhouettes

To control the transparency of silhouettes (and their color, thickness, etc.), head to Interface > Preferences > Rendering > Silhouettes. To learn more, head to the corresponding documentation page.

Documentation updates#

Stay on top of your workflow with updated guides and tutorials:

You can also find many focused SAMSON tips on the blog!

Upcoming Events#

Stephane Redon (CEO) and Dmitriy Marin (CSO) will be at the Drug Discovery Chemistry (Europe) conference in Barcelona, Spain, November 11-13, 2025. Want to discuss how SAMSON can integrate your resources and streamline molecular design? Schedule a chat with them.

Coming next#

We will introduce a few major developments before the end of the year, and we can't wait to announce them. Meanwhile, if you have feature requests or feedback, please let us know!

Thank you for being part of our growing community!