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January 2026#

This is the first issue of our 2026 monthly newsletter - your quick update on the latest SAMSON developments, new features, and what's coming next, and we have tons of exciting things in the works for you!

OpenAMI Consortium launch#

OpenAMI website

We're starting 2026 with a major announcement: the launch of OpenAMI — the Consortium for Artificial Molecular Intelligence.

OpenAMI brings together pharmas, CROs, biotechs, AI builders, and compute partners to co-develop a shared architecture that turns cutting-edge molecular AI into interoperable services, workflows, and agentic systems.

OpenAMI is a two-year consortium program, driven by a member-steered roadmap with structured voting so members directly influence priorities and deliverables.

At the core of OpenAMI is OSCAR (Orchestrated Service Cloud for Automated Research) — OneAngstrom's platform to deploy models, workflows, and agents so they can be accessed consistently across web apps, APIs, desktop, SAMSON extensions, and notebooks ("deploy once, access everywhere").

To learn more and find out how OpenAMI can benefit your organization, visit openami.io.

SAMSON#

New ways to search and select structures:

  • Find substructures by specifying an arbitrary target using SMILES/SMARTS (Select > Chemistry > Select using SMARTS).
  • Select D-amino acids by their standard PDB names (Select > Residues > D-amino acids or NSL: residue.daa).
  • Select crystallization buffer agents by their standard names (Select > Biology > Crystallization buffer agent or NSL: node.category cba).

SAMSON Extensions#

Updates:

  • Python Scripting: You can now access exposed functionality from SAMSON Extensions via new bindings for the SAMSON API and its Introspection mechanism. New Python bindinds includes: SBValue, SBProxy, SBFunction. Learn more in the Python Scripting Guide — Introspection: using extensions. This release also includes minor improvements to the SAMSON API Python bindings.
  • Exposed Functionality Viewer: Alongside improved C++ sample-code generation for exposed Extension functions, the tool now also generates Python sample code for use with integrated Python Scripting. Search performance has also been improved.
  • Importers Collection: When loading XYZ files, the structure hierarchy is now created from connected components. The same approach is applied to PDB files that contain no hierarchy. You can adjust this setting (and other importer options) in Preferences > Importers.

Minor improvements:

  • Interaction designer: We fixed several bugs, improved performance, and made quality-of-life enhancements to streamline the overall experience.

Documentation updates#

We refreshed tutorials for SAMSON and SAMSON Extensions, and added/updated resources for developers:

You can also find many focused SAMSON tips on the blog!

What's coming next in SAMSON?#

We will introduce a few major developments soon, and we can't wait to announce them. Meanwhile, if you have feature requests or feedback, please let us know!