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December 2025 - 2025 Wrap-Up#

Welcome to the eighth edition of our monthly newsletter! For this December issue, we're taking a step back and highlighting the biggest SAMSON milestones of 2025.

As always, make sure your SAMSON installation is up to date (from the menu: Interface > Update SAMSON, or with the installer).

2025 highlights#

SAMSON became free for non-commercial use#

One of the most impactful updates this year: SAMSON and every SAMSON Extension on SAMSON Connect are now free for non-commercial use (academic, nonprofit, education, and personal non-revenue projects). If you haven't switched yet, you can do it from the Pricing page on SAMSON Connect.

Major releases: SAMSON 2025 R1, R2, and R3#

2025 brought major core improvements across the platform:

  • SAMSON 2025 R1 introduced major workflow upgrades for molecular design, including the Interaction Designer, Pattern Builders, an updated Protein Aligner, Quick Groups, and new visualization tooling and color schemes.
  • SAMSON 2025 R2 expanded navigation and inspection with Progressive Clipping, plus new editors (including the View editor and Point selection editor).
  • SAMSON 2025 R3 delivered quality-of-life enhancements like Extended NSL, improved Gaussian surfaces, and clickable tooltips with fast access to SAMSON AI.

If you missed any of these releases, you can explore the full details in the release notes:

Platform & ecosystem highlights#

Better structure access and preparation workflows#

The redesigned Structure Fetcher (Home > Fetch) became a major productivity boost, expanding access to public databases and enabling IUPAC/SMILES-to-3D conversion directly into the document: Structure Fetcher extension

AI in SAMSON#

SAMSON AI kept improving throughout the year, including tighter integration with NSL generation and selection workflows:

Biomolecular structure prediction in a few clicks#

Structure prediction workflows continued to expand, including support for Boltz-2 and streamlined job sharing and downstream interaction-diagram generation:

Open science and community growth#

Adenita became open source, making it easier than ever for the community to contribute:

Partnerships and scientific extensions#

2025 also reinforced SAMSON's mission as a platform connecting best-in-class tools and collaborators:

Recent updates#

A few noteworthy improvements that were recently shipped:

  • Interaction Designer: you can now rotate or flip interaction diagrams, and diagram colors now match SAMSON's default atom colors using the CPK scheme. Check out this short video to see it in action:

  • GROMACS Wizard: improved usability with searchable advanced parameters (name + description) and direct links to relevant GROMACS manual sections.

  • OpenMM Wizard: updated to align with OpenMM v8.4.0.
  • NSL: new attributes for D-amino acids (residue.dAminoAcid) and crystallization buffer agents (node.category crystallizationBufferAgent).
  • Structure Validation: expanded aliases for better identification of non-standard amino acids on import.

Documentation & learning resources#

To support faster onboarding, better workflows, and AI-enabled tooling, the documentation ecosystem continued to grow:

Coming next#

We're continuing to invest in major platform developments, with a focus on workflow acceleration, automation, and new core capabilities. If you have feature requests or feedback, please let us know!

Thank you for being part of our growing community!