May 2025#

This is the first issue of our new monthly newsletter, designed to keep you up to date on the latest SAMSON developments, new features, collaborations, and upcoming events.

New Partnership#

We’re pleased to announce a new partnership between OneAngstrom and Prosilico AB to bring advanced ADME/PK modeling tools to SAMSON users. The first result of this collaboration is already available as a SAMSON Extension (see below).

New partnership: OneAngstrom and Prosilico

SAMSON Extensions#

New#

ANDROMEDA Demo: developed with Prosilico AB, this free extension predicts several human ADME/PK properties (3 of ~30 available in the full version).
Molecular Restrainer: created with the Orts group at Vienna University, this extension combines NMR restraints with interactive simulation to study protein-ligand interactions. See publication.

Updates#

Importers Collection: you can now import .smi files with one SMILES code per line and optional molecule names.
Interaction Designer: interactions are now shown in 3D and synchronized with the viewport. Interaction symbols are now also movable in 2D.
Python Scripting: new API features allow you to compute and manage hydrogen bonds programmatically. See documentation.
Animations: the "Simulate" animation now exposes parameters like step size and frame steps in the Inspector.

Bug Fixes#

Resolved issues with the serialization of secondary structure visual models and animations, particularly when references to deleted nodes were present.

SAMSON 2025 R1 (Patch v7.0.1) Available#

SAMSON v7.0.1 is now available. This patch includes:

Minor rendering improvements
Fixes for audio and microphone setup (especially on macOS)
Other small enhancements

To update: use Interface > Update SAMSON, or download the installer.

For developers

For developers of SAMSON Extensions: the v7.0.1 changelog is available.

Documentation Updates#

The Documentation Center, User Guide, and Developer Guide now include llms.txt and llms-full.txt files to support LLM-based tools and workflows.

Upcoming Webinar: SAMSON 2025#

We invite you to the upcoming SAMSON 2025 webinar, where we will introduce new features and workflows.

Highlights include:

Creating 2D/3D protein-ligand interaction diagrams
Using Pattern Builders for faster design
Aligning protein sequences and structures with the updated Protein Aligner
Managing selections with Quick Groups
Applying new color schemes for better visualization

Date: June 17, 2025. Time: 8am PST, 11am EST, 5pm CET. Register here !

SAMSON 2025 R1 webinar

Coming Soon#

A preview of features currently in development:

Progressive Clipping for improved visibility control. See post.

The upcoming release of SAMSON introduces progressive clipping, and I love using it. I think it enhances clarity even further, and the smooth transitions give a great sense of where you are. pic.twitter.com/IfrW6bzpXX
— Stephane Redon (@StephaneRedon) May 23, 2025

New editors for easier navigation:
- View editor
- Point selection editor

Have suggestions or feature requests? Let us know.